What is Amox TR-K CLV?

Amox TR-K CLV is a penicillin antibiotic. It is a combination medication consisting of Amoxicillin and Clavulanate Potassium. Also referred to as Co-Amoxiclav, it is perhaps better known by the brand name Augmentin.


As an antibiotic, Amoxicillin fights bacteria. However, certain bacteria can be resistant to some types of penicillin antibiotics. Clavulanate Potassium, a clavulanic acid, acts to guard against bacteria which may be resistant to amoxicillin in this way.

What is Amox TR-K CLV used for?

Amox TR-K CLV is used to treat bacterial infections by preventing their growth. Some examples of infections for which this medication is indicated in the treatment of include:

  • Bacterial infections of the skin such as boils or cellulitis
  • Respiratory Tract Infections affecting the airways such as a sinus infection or strep throat
  • Ear Infections
  • Sexually Transmitted Diseases (STDs) such as Herpes or Chlamydia
  • Urinary Tract Infections affecting the kidneys, bladder or urethra.
  • Chronic Bronchitis (acute exacerbations)
  • Bacterial infections of the mouth such as tooth infections

How to take Amox TR-K CLV?

As with any prescription medication, it is essential that Amox TR-K CLV is taken exactly as has been prescribed by your doctor. There will be a set dosage to be taken at certain intervals, and this should be followed to the letter.

Most commonly this medication will be taken every 8-12 hours, but this is not definitive and can vary. The specific dosage prescribed for you will depend on your medical condition and your subsequent response to treatment.

Your doctor will also indicate for how long the medication should be taken, and it is important not to extend your use of the drug beyond this timeframe. Conversely, even if your symptoms have improved you should not prematurely stop taking the medication before the end date of the prescription. The prescription label on your medication packet will outline all of this information clearly.

Amox TR-K CLV can be administered in a number of forms including regular, chewable and extended release. It is very important to note that the various types will not all be of the same strength (amount of clavulanate potassium varies) and for this reason it is not advisable to interchange between these forms without consulting your doctor and obtaining a new dosage prescription.

Amox TR-K CLV can result in nausea and even vomiting if taken on an upset stomach, for this reason it is recommended to take the medication with a meal and a glass of water to prevent this from happening. As previously, sticking strictly to the prescription is paramount and when possible you should take the medication at the same time every day. Skipping a dose can sometimes result in the proliferation of an infection which is resistant to antibiotics.

The regular and extended release forms of this medication cannot be chewed or crushed; they must be swallowed whole with a glass of water. For some people swallowing a tablet whole in this way can be difficult, and if necessary it is acceptable to break the tablet in half and swallow each of these halves separately. Alternatively the chewable form of the medication can be used. This should not be swallowed whole; it needs to be well chewed prior to swallowing.

In terms of storage, tablets should be kept at room temperature, excessive moisture or heat could have an adverse effect. They should be kept out of reach of children at all times

Should you still have difficulty in taking the medication in tablet form, speak to your doctor about possible alternative methods of administration. Amox TR-K CLV can also sometimes be provided in liquid form to be taken orally. If you are prescribed the medication in this manner, the liquid needs to be shaken well prior to use so that both of the medications involved are adequately mixed together.

You will most likely be given a set amount of the liquid to take and need to measure this yourself. Do not guess the volume of liquid, use a measuring instrument such as a measuring spoon or container. If you do not possess one of these instruments ask your doctor or pharmacist where to find one.

The liquid form of Amox TR-K CLV should be stored in the refrigerator, if not refrigerated it can they can lose their effectiveness prior to the expiration date. Should you have any remaining unused liquid it is advised to dispose of it after ten days. As with the tablet form, it should always be well out of reach of children.

How Amox TR-K CLV works?

Amoxicillin is a semi-synthetic penicillin. It effectively works by breaking down the membrane of bacterial cells and therefore causing cell death. In order to do this it prevents the production of peptidoglycan which is the main component of the cell walls of most bacteria forming a mesh of sugar and amino acids.

Specifically it inhibits the enzymes (or penicillin-binding proteins) wnmhich are essential in the process by which peptidoglycan is synthesised.

However, certain antibiotic resistant medications produce beta-lactamase enzymes which can prevent the effectiveness of Amoxicillin in carrying out this process of peptidoglycan inhibition. This is where the Clavulanate Potassium component of Amox TK-R CLV comes into play. While it is a beta-lactum, it is also related to penicillin in terms of having a similar structural make-up. Clavulanate Potassium would not independently have any useful anti-bacterial affects.

However, in this instance it works to prevent the action of the aforementioned beta-lactamase enzymes. In this way it reduces the risk of bacteria successfully resisting the action of Amoxicillin in breaking down bacterial cell membranes and ultimately causing cell death.

Side Effects

Amox TR-K CLV can sometimes result in unwanted side effects. However, for the majority of patients this will not be the case. In clinical trials carried out to determine the risks involved in taking this medication, a very low number of participants needed to discontinue using it due to side effects (less than three percent).

For those who do suffer adverse effects they will most likely commonly be mild and last only for a short time. However, should you suffer from any of the following side effects it is important to check with your doctor immediately, as some may require medical attention.

  • Diarrhoea and/or blood in stools
  • Nausea and/or vomiting
  • Skin Rash, redness of the skin, or hives.
  • Itching, particularly in the vaginal or genital region
  • Dark coloured urine and/or change in frequency of urinating (either increased or decreased)
  • Bleeding or bruising more easily than usual
  • Jaundice (yellowing of skin or eyes) or pale skin
  • Headaches
  • Fever, sometimes with associated confusion or weakness
  • Heartburn
  • Swelling, can be of face, tongue, lower legs and/or feet

Dosage

As previously mentioned, Amox TR-K CLK should be taken exactly as prescribed by your doctor. The following dosage information is not a substitute for medical advice, and should not be used to inform the dosage you take as a patient. This is because the specific dosage will vary for each patient due to a number of factors. These factors can include:

  • The condition being treated and the severity of the infection
  • Your age (dosage for adults will be higher than dosage for children)
  • Your past medical history
  • Your height and body mass index

As a guide, some common prescription dosages of Amox TR-K CLK include one 250mg/125mg tablet every eight hours or one 500mg/125mg tablet every twelve hours.

Should the condition being treated be more serious, for example in the case of a respiratory tract infection, the dosages may be increased. For example one Amox TR-K CLK 500mg/250mg tablet every eight hours or one Amox TR-K CLK 875mg/250mg tablet every twelve hours.

Should someone take an excess amount of Amox TR-K CLV and overdose on the medication, you should contact the emergency services immediately. Severe symptoms of overdose include loss of consciousness and difficulty breathing. Other less serious symptoms such as severe vomiting, persistent diarrhoea, drowsiness or severe stomach pain can also be signs of an overdose.

Is there any difference between Amox TR-K CLV 875-125mg and Amoxicillin 875 MG?

This is a frequently asked question as it can be unclear if there is any difference between these two medications. However, they are in fact quite different.

Amoxicillin 875mg is a medication consisting of 875 milligrams of the antibiotic Amoxicillin in isolation with no other ingredients.

Amox TR-K CLV 875mg/125mg tablets on the other hand, are a combination medication consisting of two ingredients, namely the antibiotic Amoxicillin and the clavulanic acid called Clavulanate Potassium. It is alternatively known as Co-Amoxiclav or by the brand name Augmentin. The 875mg refers to the quantity of Amoxicillin in the mixture and the 125mg refers to the quantity of Clavulanate Potassium.

The reason for combining these two ingredients is that Clavulanate Potassium prevents resistant bacteria from destroying the Amoxicillin so that it is able to continue to act effectively on the bacterial cell membranes and ultimately kill the bacterial cells.

Precautions to Take

For precautions relating to how you should take Amox TR-K CV once it has been prescribed, see the “How to Take” section.

Prior to beginning a course of Amox TR-K CLV there are a number of precautions which it is important to take note of. Should you feel that any of the following precautions may be relevant to you, be sure to inform your doctor. These precautions include:

  • If you are allergic to Penicillin, Amoxicillin, or Clavulanate Potassium. It is also advised to inform your doctor of any other allergies you may have, as there can be inactive ingredients in the medication that may result in an allergic reaction.
  • A past history of liver disease, kidney issues or jaundice.
  • If you suffer from asthma, hives, hay fever or mononucleosis.
  • If you are pregnant or planning to become pregnant.  You may need to discuss the possible risks and benefits of taking this medication during pregnancy with your doctor.
  • If there are any impairments of your renal function

Other precautionary considerations:

  • This medication can sometimes cause nausea and dizziness, which can be made worse by the consumption of alcohol. In any case, while you are feeling unwell it is best to avoid alcohol as it will only worsen your symptoms.
  • If you are on birth control, it is advised to use an added form of contraception such as a condom during sexual intercourse. This is because some antibiotics have been found to reduce the effectiveness of birth control medication which is being taken concurrently.
  • It is a common misconception that the anti-inflammatory medication Ibuprofen should never be taken concurrently with an antibiotic. However, in most cases if there are no impairments of your liver function there will not be an issue. Ask your doctor to confirm that these medications are safe for you to take together.
  • In rare cases Amox TR-K CLV can cause you to be more sensitive to the sun. For this reason it may be advisable in some cases to avoid direct sun exposure if possible and to ensure to wear a high factor sunscreen when outdoors.

References:

  1. http://www.newhealthguide.org/Amox-Tr-K-Clv.html
  2. https://www.drugs.com/answers/amox-tr-clv-875-125-mg-tab-differ-amoxicillin-875-2432718.html
  3. https://www.patientslikeme.com/treatments/show/4439-amox-trk-clv-side-effects-and-efficacy?brand=t#overview
  4. http://www.webmd.com/drugs/2/drug-1922-6240/amoxicillin-potassium-clavulanate-oral/amoxicillin-clavulanic-acid—oral/details#precautions
  5. https://medlineplus.gov/druginfo/meds/a685024.html
  6. https://www.rxwiki.com/amoxicillin-clavulanate#overview
  7. https://www.drugs.com/amoxicillin_clavulanate.html
  8. https://www.medicines.org.uk/emc/medicine/19191
  9. https://en.wikipedia.org/wiki/Amoxicillin/clavulanic_acid#
  10. https://www.agingcare.com/articles/extreme-temperatures-may-affect-medication-152125.htm

Published on by under Drugs and Medications.
Article was last reviewed on May 28th, 2017.

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